Latest Analagesics & Antipyretics Objective Type Questions And Answers

61. Which of the following durgs is a monamine oxidase inhibitor, but is used to treat hypertension?
(a) Tranylcypromine (Parnate)
(b) Reserpine
(c) Propranolol (Inderal)
(d) Pargyline (Eutonyl)
(e) Imipramine (Tofranil)
Ans: D

62. Autacoids differ from hormones in that
(a) Autacoids are involved only in the causation of pathological states
(b) Autacoids do not have a specific cell/ tissue of origin
(c) Autacoids generally act locally at the site of generation and release
(d) Both (b) and (c)
Ans: D

63. Which of the following eicosanoids is generated through the lipozygenase pathway ?
(a) Prostaglandin E2
(b) Thromboxane A2
(c) Prostacyclin
(d) Leukotriene C4
Ans: D

64. The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that
(a) They catalyse different pathways in prostanoid biosynthesis
(b) COX–1 is inhibited by aspirin but not COX–2
(c) COX–2 is inhibited by ibuprofen but not COX–1
(d) COX–1 is constitutive while COX–2 is inducible
Ans: D

65. Which of the following is an irreversible inhibitor of cyclooxygenase ?
(a) Aspirin
(b) Phenylbutazone
(c) Indomethacin
(d) Piroxicam
Ans: A

66. The prostanoid that consistently constricts blood vessels is
(a) Prostaglandin E2
(b) Prostaglandin F2a
(c) Thromboxane A2
(d) Prostacyclin
Ans: C

67. The following prostanoid is a potent inducer of platelet aggregation
(a) Prostacyclin
(b) Prostaglandin E2
(c) Prostaglandin D2
(d) Thromboxane A2
Ans: D

68. Aspirin in low doses produces longlasting inhibition
(a) Platelets contain low quantity of COX
(b) Platelets cannot synthesize fresh COX molecules
(c) Platelets bind aspirin with high affinity
(d) Platelet COX is inducible
Ans: B

69. The early pregnancy uterus is sensitive to the following oxytocic
(a) Oxytocin
(b) Methylergometrine
(c) Prostaglandin F2a
(d) Both (a) and (b)
Ans: C

70. Cervical priming with prostaglandin results in
(a) Facilitation of sperm movement through cervical canal
(b) Increased cervical tone
(c) Softening of cervix
(d) Increased cervical secretions
Ans: C

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