Analagesics & Antipyretics Multiple Choice Questions And Answers

21. Cyclooxygenase-1 and –2 are responsible for
(a) The synthesis of prostaglandins from arachidonate
(b) The synthesis of leukotrienes from arachidonate
(c) The conversion of ATP to cAMP
(d) The metabolic degradation of cAMP
(e) The conversion of GTP to cGMP
Ans: A

22. Following agent is generally used in allergic rhinitis
(a) Beclomethasone
(b) Fluticasone
(c) Triamcinolone
(d) All of the above
Ans: D

23. The primary objective for designing drugs that selectively inhibit COX – 2 is to
(a) Decrease the risk of nephrotoxicity
(b) Improve anti-inflammatory effectiveness
(c) Lower the risk of gastrointestinal toxicity
(d) Reduce the cost of treatment of rheumatoid arthritis
(e) Selectively decrease thromboxane A2 without effects on other eicosanoids
Ans: C

24. A newborn was diagnosed as having a congenital abnormality that resulted in transposition of her great arteries. While preparing the infant for surgery, the
medical team needed to keep the ductus arteriosus open. They did this by infusing
(a) Cortisol
(b) Indomethacin
(c) Ketorolac
(d) Misoprostol
(e) Tacrolimus
Ans: D

25. Acetyl salicylic acid is soluble in
(a) An aqueous base
(b) Water
(c) An aqueous acid
Ans: A

26. Decomposition of the acetyl salicylic acid at room temperature most likely would occur by
(a) Oxidation of the ester
(b) Reduction of the carboxylic acid
(c) Hydrolysis of the ester
Ans: C

27. Diamprit is an agonist of ______ receptors, except
(a) H1
(b) H2
(c) H3
(d) All of the above
Ans: A

28. Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions?
(a) Phospholipase
(b) Lipoxygenase
(c) Cyclooxygenase-I
(d) Cyclooxygenase II
(e) Xanthine oxidase
Ans: D

29. Which of the following prostaglandin analogs is used specifically for the treatment of NSAID induced gastrointestinal ulcertation?
(a) Alprostadil
(b) Misoprostol
(c) Carboprost
(d) Dinoprostone
(e) Epoprostenol
Ans: B

30. Which of the following compounds is most likely to lower circulating levels of leukotrienes?
(a) Zileuton
(b) Montelukast
(c) Carprofen
(d) Aspirin
(e) Allopurinol
Ans: A

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