61. A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in the prostate and writes a prescription for
(a) Atropine
(b) Clonidine
(c) Hydralazine
(d) Neostigmine
(e) Propranolol
Ans: B
62. Action of norepinephrine and epinephrine are terminated by
(a) Reuptake into nerve terminal
(b) Dilution by diffusion and uptake at extraneuronal site
(c) Metabolic transformation
(d) All of the above
Ans: D
63. Typical results of beta-receptor activation include which one of the following?
(a) Hypoglycemia
(b) Lipolysis
(c) Glycogen synthesis
(d) Decreased skeletal muscle tremor
(e) Decreased rennin secretion
Ans: B
64. A patient is admitted to the emergency room with orthostatic hypotension and evidence of marked GI bleeding. Which of the following most accurately describes
the probable autonomic response to this bleeding?
(a) Slow heart rate, dilated pupils, damp skin
(b) Rapid heart rate, dilated pupils, damp skin
(c) Slow heart rate, dry skin, increased bowel sounds
(d) Rapid heart rate, constricted pupils, increased bowel sounds
(e) Rapid heart rate, constricted pupils, warm skin
Ans: B
65. Drugs that block the a receptor on effector cells at adrenergic nerve endings
(a) Antagonize the effects of isoproterenol on the heart rate
(b) Antagonize some of the effects of epinephrine on the blood pressure
(c) Antagonize the effects of epinephrine on adenylyl cyclase
(d) Cause mydriasis
(e) Decreases blood glucose levels
Ans: B
66. Yohimbine is an antagonist of ______ receptors.
(a) a1
(b) a2
(c) both (a) and (b)
(d) None of the above
Ans: B
67. Which of the following organs is innervated only by parasympathetic nerves ?
(a) Iris muscles
(b) Ciliary muscle
(c) Sweat glands
(d) Splenic capsule
Ans: B
68. Muscarinic cholinergic receptors
(a) Are located only on parasympathetically innervated effector cells
(b) Mediate responses by opening an instrinsic Na+ ion channel
(c) Are present on vascular endothelium which has no cholinergic nerve supply
(d) Predominate in the autonomic ganglia
Ans: C
69. The cardiac muscarinic receptors
(a) Are of the M1 subtype
(b) Are of the M2 subtype
(c) Are selectively blocked by pirenzepine
(d) Function through the PIP2 ? IP3/DAG pathway
Ans: B
70. Atropine does not exert relaxant/ antispasmodic effect on the following muscle
(a) Intestinal
(b) Ureteric
(c) Bronchial
(d) Layngeal
Ans: D
(a) Atropine
(b) Clonidine
(c) Hydralazine
(d) Neostigmine
(e) Propranolol
Ans: B
62. Action of norepinephrine and epinephrine are terminated by
(a) Reuptake into nerve terminal
(b) Dilution by diffusion and uptake at extraneuronal site
(c) Metabolic transformation
(d) All of the above
Ans: D
63. Typical results of beta-receptor activation include which one of the following?
(a) Hypoglycemia
(b) Lipolysis
(c) Glycogen synthesis
(d) Decreased skeletal muscle tremor
(e) Decreased rennin secretion
Ans: B
64. A patient is admitted to the emergency room with orthostatic hypotension and evidence of marked GI bleeding. Which of the following most accurately describes
the probable autonomic response to this bleeding?
(a) Slow heart rate, dilated pupils, damp skin
(b) Rapid heart rate, dilated pupils, damp skin
(c) Slow heart rate, dry skin, increased bowel sounds
(d) Rapid heart rate, constricted pupils, increased bowel sounds
(e) Rapid heart rate, constricted pupils, warm skin
Ans: B
65. Drugs that block the a receptor on effector cells at adrenergic nerve endings
(a) Antagonize the effects of isoproterenol on the heart rate
(b) Antagonize some of the effects of epinephrine on the blood pressure
(c) Antagonize the effects of epinephrine on adenylyl cyclase
(d) Cause mydriasis
(e) Decreases blood glucose levels
Ans: B
66. Yohimbine is an antagonist of ______ receptors.
(a) a1
(b) a2
(c) both (a) and (b)
(d) None of the above
Ans: B
67. Which of the following organs is innervated only by parasympathetic nerves ?
(a) Iris muscles
(b) Ciliary muscle
(c) Sweat glands
(d) Splenic capsule
Ans: B
68. Muscarinic cholinergic receptors
(a) Are located only on parasympathetically innervated effector cells
(b) Mediate responses by opening an instrinsic Na+ ion channel
(c) Are present on vascular endothelium which has no cholinergic nerve supply
(d) Predominate in the autonomic ganglia
Ans: C
69. The cardiac muscarinic receptors
(a) Are of the M1 subtype
(b) Are of the M2 subtype
(c) Are selectively blocked by pirenzepine
(d) Function through the PIP2 ? IP3/DAG pathway
Ans: B
70. Atropine does not exert relaxant/ antispasmodic effect on the following muscle
(a) Intestinal
(b) Ureteric
(c) Bronchial
(d) Layngeal
Ans: D
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