51. A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is
(a) Acetazolamide
(b) Amiloride
(c) Furosemide
(d) Hydrochlorothiazide
(e) Spironolactone
Ans: A
52. Oxytremorine is a selective agonist of muscarinic _______ receptors
(a) M1
(b) M2
(c) M3
(d) M4
Ans: A
53. A drug that is useful in glaucoma and high-altitude sickness is
(a) Acetazolamide
(b) Amiloride
(c) Demeclocycline
(d) Desmopressin
(e) Ethacrynic acid
Ans: A
54. Cromolyn has as its major action
(a) Block of calcium channels in lymphocytes
(b) Block of mediator release from mast cells
(c) Block of phosphodiesterase in mast cells and basophils
(d) Smooth muscle relaxation in the bronchi
(e) Stimulation of cortisol release by the adrenals
Ans: B
55. Following events occur in the cytoplasm and not inside storage vesicles, except
(a) Conversion of tyrosine to dopa
(b) Conversion of dopa to dopamine
(c) Conversion of dopamine to norepinephrine
(d) Conversion of dopamine to 3,4 dihydroxy phenyl acetic acid
Ans: C
56. Which one of the following is lest likely to be useful in the therapy of hypercalcemia?
(a) Calcitonin
(b) Glucocorticoids
(c) Plicamycin
(d) Parenteral infusion of phosphate
(e) Thiazide diuretics
Ans: E
57. Characteristics of Vitamin D and its metabolites include which one of the following?
(a) Act to decrease serum levels of calcium
(b) Activation of their Vitamin D receptors increases cellular CAMP
(c) Calcitriol is the major derivative responsible for increasing intestinal absorption of phosphate
(d) Metabolites of Vitamin D increase renal excretion of calcium
(e) Vitamin D deficiency results in Pager’s disease
Ans: C
58. Which of the following conditions is an indication for the use of calcitonin?
(a) Chronic renal failure
(b) Hypoparathyroidism
(c) Intestinal osteodystrophy
(d) Pager’s disease
(e) Rickets
Ans: D
59. Clinical uses of Vitamin D do not include
(a) Chronic renal failure
(b) Hyperparathyroidism
(c) Intestinal osteodystrophy
(d) Nutritional rickets
(e) Osteoporosis
Ans: B
60. Which one of the following drugs, when used chronically, is associated with the development of bone pain and mineralization defects such as osteomalacia?
(a) Calcitonin
(b) Dihydrotachysterol
(c) Ergocalciferol
(d) Etidronate
(e) Norgestrel
Ans: D
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(a) Acetazolamide
(b) Amiloride
(c) Furosemide
(d) Hydrochlorothiazide
(e) Spironolactone
Ans: A
52. Oxytremorine is a selective agonist of muscarinic _______ receptors
(a) M1
(b) M2
(c) M3
(d) M4
Ans: A
53. A drug that is useful in glaucoma and high-altitude sickness is
(a) Acetazolamide
(b) Amiloride
(c) Demeclocycline
(d) Desmopressin
(e) Ethacrynic acid
Ans: A
54. Cromolyn has as its major action
(a) Block of calcium channels in lymphocytes
(b) Block of mediator release from mast cells
(c) Block of phosphodiesterase in mast cells and basophils
(d) Smooth muscle relaxation in the bronchi
(e) Stimulation of cortisol release by the adrenals
Ans: B
55. Following events occur in the cytoplasm and not inside storage vesicles, except
(a) Conversion of tyrosine to dopa
(b) Conversion of dopa to dopamine
(c) Conversion of dopamine to norepinephrine
(d) Conversion of dopamine to 3,4 dihydroxy phenyl acetic acid
Ans: C
56. Which one of the following is lest likely to be useful in the therapy of hypercalcemia?
(a) Calcitonin
(b) Glucocorticoids
(c) Plicamycin
(d) Parenteral infusion of phosphate
(e) Thiazide diuretics
Ans: E
57. Characteristics of Vitamin D and its metabolites include which one of the following?
(a) Act to decrease serum levels of calcium
(b) Activation of their Vitamin D receptors increases cellular CAMP
(c) Calcitriol is the major derivative responsible for increasing intestinal absorption of phosphate
(d) Metabolites of Vitamin D increase renal excretion of calcium
(e) Vitamin D deficiency results in Pager’s disease
Ans: C
58. Which of the following conditions is an indication for the use of calcitonin?
(a) Chronic renal failure
(b) Hypoparathyroidism
(c) Intestinal osteodystrophy
(d) Pager’s disease
(e) Rickets
Ans: D
59. Clinical uses of Vitamin D do not include
(a) Chronic renal failure
(b) Hyperparathyroidism
(c) Intestinal osteodystrophy
(d) Nutritional rickets
(e) Osteoporosis
Ans: B
60. Which one of the following drugs, when used chronically, is associated with the development of bone pain and mineralization defects such as osteomalacia?
(a) Calcitonin
(b) Dihydrotachysterol
(c) Ergocalciferol
(d) Etidronate
(e) Norgestrel
Ans: D
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