41. Of the following which is the most important mechanism of concurrent acquisition of multidrug resistance among bacteria ?
(a) Mutation
(b) Conjugation
(c) Transduction
(d) Transformation
Ans: B
42. Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because
(a) They produce a ß-lactamase which destroys methicillin and related drugs
(b) They elaborate an amidase which destroys methicillin and related drugs
(c) They have acquired a penicillin binding protein which has low affinity for ß-lactam antibiotics
(d) They are less permeable to ß-lactam antibiotics
Ans: C
43. A man has an Escherichia coli bacteremia with a low-grade fever (101.6°F).
Appropriate management of his fever would be
(a) Give acetaminophen 650 mg orally every 4 hours
(b) Give aspirin 650 mg orally every 4 hours
(c) Give alternating doses of aspirin and acetaminophen every 4 hours
(d) Withhold antipyretics, and use the fever curve to monitor his response to antibiotic therapy
(e) Use tepid water baths to reduce the fever
Ans: D
44. Superinfections are more common with
(a) Use of narrow spectrum antibiotics
(b) Short courses of antibiotics
(c) Use of antibiotics that are completely absorbed from the small intestines
(d) Use of antibiotic combinations covering both gram positive and gram negative bacteria
Ans: D
45. Select the antibiotic whose dose must be reduced in patients with renal insufficiency
(a) Ampicillin
(b) Chloramphenicol
(c) Tobramycin
(d) Erythromycin
Ans: C
46. Which antimicrobial should be avoided in patients of liver disease ?
(a) Chlortetracycline
(b) Cotrimoxazole
(c) Cephalexin
(d) Ethambutol
Ans: A
47. What is break point concentration of an antibiotic ?
(a) Concentration at which the antibiotic lyses the bacteria
(b) Concentration of the antibiotic which demarks between sensitive and resistant bacteria
(c) Concentration of the antibiotic which overcomes bacterial resistance
(d) Concentration at which a bacteriostatic antibiotic becomes bactericidal
Ans: B
48. Which type of antimicrobial drug combination is most likely to exhibit antagonism ?
(a) Bactericidal + Bactericidal
(b) Bactericidal + Bacteriostatic for a highly sensitive organism
(c) Bactericidal + Bacteriostatic for a marginally sensitive organism
(d) Bacteriostatic + Bacteriostatic
Ans: B
49. Indicate the sulfonamide whose sodium salt yields a nearly neutral solution which is suitable for topical use in the eye
(a) Sulfadiazine
(b) Sulfacetamide
(c) Sulfamerazine
(d) Sulfamethizole
Ans: B
50. Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because
(a) They have produced serious cutaneous reactions
(b) They have produced high incidence of crystalluria
(c) They interact with many drugs
(d) They do not penetrate blood-brain barrier
Ans: A
(a) Mutation
(b) Conjugation
(c) Transduction
(d) Transformation
Ans: B
42. Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because
(a) They produce a ß-lactamase which destroys methicillin and related drugs
(b) They elaborate an amidase which destroys methicillin and related drugs
(c) They have acquired a penicillin binding protein which has low affinity for ß-lactam antibiotics
(d) They are less permeable to ß-lactam antibiotics
Ans: C
43. A man has an Escherichia coli bacteremia with a low-grade fever (101.6°F).
Appropriate management of his fever would be
(a) Give acetaminophen 650 mg orally every 4 hours
(b) Give aspirin 650 mg orally every 4 hours
(c) Give alternating doses of aspirin and acetaminophen every 4 hours
(d) Withhold antipyretics, and use the fever curve to monitor his response to antibiotic therapy
(e) Use tepid water baths to reduce the fever
Ans: D
44. Superinfections are more common with
(a) Use of narrow spectrum antibiotics
(b) Short courses of antibiotics
(c) Use of antibiotics that are completely absorbed from the small intestines
(d) Use of antibiotic combinations covering both gram positive and gram negative bacteria
Ans: D
45. Select the antibiotic whose dose must be reduced in patients with renal insufficiency
(a) Ampicillin
(b) Chloramphenicol
(c) Tobramycin
(d) Erythromycin
Ans: C
46. Which antimicrobial should be avoided in patients of liver disease ?
(a) Chlortetracycline
(b) Cotrimoxazole
(c) Cephalexin
(d) Ethambutol
Ans: A
47. What is break point concentration of an antibiotic ?
(a) Concentration at which the antibiotic lyses the bacteria
(b) Concentration of the antibiotic which demarks between sensitive and resistant bacteria
(c) Concentration of the antibiotic which overcomes bacterial resistance
(d) Concentration at which a bacteriostatic antibiotic becomes bactericidal
Ans: B
48. Which type of antimicrobial drug combination is most likely to exhibit antagonism ?
(a) Bactericidal + Bactericidal
(b) Bactericidal + Bacteriostatic for a highly sensitive organism
(c) Bactericidal + Bacteriostatic for a marginally sensitive organism
(d) Bacteriostatic + Bacteriostatic
Ans: B
49. Indicate the sulfonamide whose sodium salt yields a nearly neutral solution which is suitable for topical use in the eye
(a) Sulfadiazine
(b) Sulfacetamide
(c) Sulfamerazine
(d) Sulfamethizole
Ans: B
50. Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because
(a) They have produced serious cutaneous reactions
(b) They have produced high incidence of crystalluria
(c) They interact with many drugs
(d) They do not penetrate blood-brain barrier
Ans: A
More Questions & Answers:-
I was cured of HPV with the use of pure natural roots and herbs from a herbal professional maker called dr Moses Buba, a man of trust and always reliable to his word. I actually thank you cause at first I doubt what others do, but you make me believe that good people still live . You can reach via email buba.herbalmiraclemedicine@gmail.com or WhatsApp him +234906059305 for more information you can reach me also on my cell phone with text or WhatsApp and even drop a call on 0(501)9914802 . am grateful to share his work so I will share more about Dr Moses buba
ReplyDeleteI was cured of HPV with the use of pure natural roots and herbs from a herbal professional maker called dr Moses Buba, a man of trust and always reliable to his word. I actually thank you cause at first I doubt what others do, but you make me believe that good people still live . You can reach via email buba.herbalmiraclemedicine@gmail.com or WhatsApp him +234906059305 for more information you can reach me also on my cell phone with text or WhatsApp and even drop a call on 0(501)9914802 . am grateful to share his work so I will share more about Dr Moses buba