21. Regarding the recently introduced lipid formulation of amphotericin B, which one of the following statements is accurate?
(a) Affinity of amphotericin B for these lipids is greater than affinity for ergosterol
(b) They are less expensive to use than conventional amphotericin B
(c) They are more effective in fungal infections
because they increase tissue uptake of amphotericin B
(d) They may decrease nephrotoxicity of amphotericin B
(e) They have wider spectrums of antifungal activity than conventional formulations of amphotericin B
Ans: D
22. Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis?
(a) Ampicillin
(b) Cefazolin
(c) Ganciclovir
(d) Tobramycin
(e) Vancomycin
Ans: E
23. The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called
(a) Time-dependent killing
(b) The post antibiotic effect
(c) Clinical synergy
(d) Concentration – dependent killing
(e) Sequential blockade
Ans: B
24. In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients?
(a) Penicillin G, imipenem, amphotericin B, metronidazol
(b) Penicillin G, chlormphenicol, tetracycline, vancomycin
(c) Imipenem, tetracycline, vancomycin, sulfadiazine
(d) Cycloserine, metronidazole, vancomycin, sulfadiazine
(e) Metronidazole, imipenem, doxycycline, erythromycin
Ans: A
25. Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes?
(a) Ciprofloxacin
(b) Cyclosporine
(c) Erythromycin
(d) Rifampin
(e) Tetracycline
Ans: D
26. Beta – lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be effective against all strains of each of the above organisms?
(a) Ampicillin
(b) Ceftriaxone
(c) Clindamycin
(d) Gentamicin
(e) Piperacillin
Ans: B
27. A 19-year-old woman with recurrent sinusitis has been treated with different antibiotics on several occasions. During the course of one such treatment she
developed a severe diarrhea and was hospitalized. Sigmoidoscopy revealed colitis, and pseudomembranes, were confirmed histologically. Which of the following drugs, administered orally, is most likely to be effective in the treatment of colitis due to C difficile?
(a) Ampicillin
(b) Cefazolin
(c) Clindamycin
(d) Metonidazole
(e) Tetracycline
Ans: D
28. Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the
drug is accurate?
(a) Acts mainly in the M phase of the cell cycle
(b) Derived from the bark of yew trees
(c) Myelosuppression is dose-limiting
(d) Peripheral neuropathy occurs in more than 50% of patients
(e) Pulmonary infiltrates and fibrosis may occur
Ans: E
29. A high school student presents with headache, fever, and cough of 2 day’s duration.
Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with
(a) Cefazolin
(b) Clindamycin
(c) Erythromycin
(d) Gentamicin
(e) Trovafloxacin
Ans: C
30. Chloramphenicol is particularly effective in the treatment of
(a) Diphtheria
(b) Tuberculosis
(c) Emphysema
(d) Rickettsial diseases
(e) Streptomyces pyogenes infections
Ans: D
(a) Affinity of amphotericin B for these lipids is greater than affinity for ergosterol
(b) They are less expensive to use than conventional amphotericin B
(c) They are more effective in fungal infections
because they increase tissue uptake of amphotericin B
(d) They may decrease nephrotoxicity of amphotericin B
(e) They have wider spectrums of antifungal activity than conventional formulations of amphotericin B
Ans: D
22. Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis?
(a) Ampicillin
(b) Cefazolin
(c) Ganciclovir
(d) Tobramycin
(e) Vancomycin
Ans: E
23. The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called
(a) Time-dependent killing
(b) The post antibiotic effect
(c) Clinical synergy
(d) Concentration – dependent killing
(e) Sequential blockade
Ans: B
24. In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients?
(a) Penicillin G, imipenem, amphotericin B, metronidazol
(b) Penicillin G, chlormphenicol, tetracycline, vancomycin
(c) Imipenem, tetracycline, vancomycin, sulfadiazine
(d) Cycloserine, metronidazole, vancomycin, sulfadiazine
(e) Metronidazole, imipenem, doxycycline, erythromycin
Ans: A
25. Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes?
(a) Ciprofloxacin
(b) Cyclosporine
(c) Erythromycin
(d) Rifampin
(e) Tetracycline
Ans: D
26. Beta – lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be effective against all strains of each of the above organisms?
(a) Ampicillin
(b) Ceftriaxone
(c) Clindamycin
(d) Gentamicin
(e) Piperacillin
Ans: B
27. A 19-year-old woman with recurrent sinusitis has been treated with different antibiotics on several occasions. During the course of one such treatment she
developed a severe diarrhea and was hospitalized. Sigmoidoscopy revealed colitis, and pseudomembranes, were confirmed histologically. Which of the following drugs, administered orally, is most likely to be effective in the treatment of colitis due to C difficile?
(a) Ampicillin
(b) Cefazolin
(c) Clindamycin
(d) Metonidazole
(e) Tetracycline
Ans: D
28. Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the
drug is accurate?
(a) Acts mainly in the M phase of the cell cycle
(b) Derived from the bark of yew trees
(c) Myelosuppression is dose-limiting
(d) Peripheral neuropathy occurs in more than 50% of patients
(e) Pulmonary infiltrates and fibrosis may occur
Ans: E
29. A high school student presents with headache, fever, and cough of 2 day’s duration.
Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with
(a) Cefazolin
(b) Clindamycin
(c) Erythromycin
(d) Gentamicin
(e) Trovafloxacin
Ans: C
30. Chloramphenicol is particularly effective in the treatment of
(a) Diphtheria
(b) Tuberculosis
(c) Emphysema
(d) Rickettsial diseases
(e) Streptomyces pyogenes infections
Ans: D
very interesting
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DeleteI was cured of HPV with the use of pure natural roots and herbs from a herbal professional maker called dr Moses Buba, a man of trust and always reliable to his word. I actually thank you cause at first I doubt what others do, but you make me believe that good people still live . You can reach via email buba.herbalmiraclemedicine@gmail.com or WhatsApp him +234906059305 for more information you can reach me also on my cell phone with text or WhatsApp and even drop a call on 0(501)9914802 . am grateful to share his work so I will share more about Dr Moses buba
I was cured of HPV with the use of pure natural roots and herbs from a herbal professional maker called dr Moses Buba, a man of trust and always reliable to his word. I actually thank you cause at first I doubt what others do, but you make me believe that good people still live . You can reach via email buba.herbalmiraclemedicine@gmail.com or WhatsApp him +234906059305 for more information you can reach me also on my cell phone with text or WhatsApp and even drop a call on 0(501)9914802 . am grateful to share his work so I will share more about Dr Moses buba
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ReplyDeleteI was cured of HPV with the use of pure natural roots and herbs from a herbal professional maker called dr Moses Buba, a man of trust and always reliable to his word. I actually thank you cause at first I doubt what others do, but you make me believe that good people still live . You can reach via email buba.herbalmiraclemedicine@gmail.com or WhatsApp him +234906059305 for more information you can reach me also on my cell phone with text or WhatsApp and even drop a call on 0(501)9914802 . am grateful to share his work so I will share more about Dr Moses buba
ReplyDeleteI was cured of HPV with the use of pure natural roots and herbs from a herbal professional maker called dr Moses Buba, a man of trust and always reliable to his word. I actually thank you cause at first I doubt what others do, but you make me believe that good people still live . You can reach via email buba.herbalmiraclemedicine@gmail.com or WhatsApp him +234906059305 for more information you can reach me also on my cell phone with text or WhatsApp and even drop a call on 0(501)9914802 . am grateful to share his work so I will share more about Dr Moses buba
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