1. Which of the following terms best describes the antagonism of leukotriene’s bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with asthma?
(a) Pharmacologic antagonist
(b) Partial agonist
(c) Physiologic antagonist
(d) Chemical antagonist
(e) Noncompetitive antagonist
Ans: C
2. If therapy with multiple drugs causes induction of drug metabolism in your asthma patient, it will
(a) Result in increased smooth endoplasmic reticulum
(b) Result in increased rough endoplasmic reticulum
(c) Result in decreased enzymes in the soluble cytoplasmic fraction
(d) Require 3-4 months to reach completion
(e) Be irreversible
Ans: A
3. The Symptoms of allergen-mediated asthma result from which of the following?
(a) Increased release of mediators from mast cells
(b) Increased adrenergic responsiveness of the airways
(c) Increased vascular permeability of bronchial tissue
(d) Decreased calcium influx into the mast cells
(e) Decreased prostaglandin production
Ans: A
4. Which of the following will result from blockade of H2 receptors?
(a) Decreased camp in cardiac muscle
(b) Increased camp in cardiac muscle
(c) Decreased IP3 in gastric mucosa
(d) Increased IP3 in gastric mucosa
(e) Increased IP3 in smooth muscle
Ans: A
5. Toxicities of H2 antihistamines include which one of the following?
(a) Blurred vision
(b) Diarrhea
(c) Orthostatic hypotension
(d) P450 inhibition
(e) Sleepiness
Ans: D
6. A patient undergoing cancer chemotherapy is vomiting frequently. A drug that might help in this situation is
(a) Bromocriptine
(b) Cimetidine
(c) Ketanserin
(d) Loratadine
(e) Ondansetron
Ans: E
7. Which of the following is most useful in the treatment of hyperprolactinemia ?
(a) Bromocriptine
(b) Cimetidine
(c) Ergotamine
(d) Ketanserin
(e) LSD
Ans: A
8. Drugs that can dilate bronchi during an acute asthmatic attack include all of the following except
(a) Epinephrine
(b) Terbutaline
(c) Nedocromil
(d) Theophyline
(e) Ipratropium
Ans: C
9. Which of the following is a nonselective but very potent and efficacious bonchodilator that is not active by the oral route?
(a) Aminophyline
(b) Cromolyn
(c) Epinephrine
(d) Ipratropium
(e) Metaproterenol
Ans: C
10. Which of the following is a prophylactic agent that appears to stabilize mast cells?
(a) Aminophyline
(b) Cromolyn
(c) Epinephrine
(d) Ipratropium
(e) Metaproterenol
Ans: B
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(a) Pharmacologic antagonist
(b) Partial agonist
(c) Physiologic antagonist
(d) Chemical antagonist
(e) Noncompetitive antagonist
Ans: C
2. If therapy with multiple drugs causes induction of drug metabolism in your asthma patient, it will
(a) Result in increased smooth endoplasmic reticulum
(b) Result in increased rough endoplasmic reticulum
(c) Result in decreased enzymes in the soluble cytoplasmic fraction
(d) Require 3-4 months to reach completion
(e) Be irreversible
Ans: A
3. The Symptoms of allergen-mediated asthma result from which of the following?
(a) Increased release of mediators from mast cells
(b) Increased adrenergic responsiveness of the airways
(c) Increased vascular permeability of bronchial tissue
(d) Decreased calcium influx into the mast cells
(e) Decreased prostaglandin production
Ans: A
4. Which of the following will result from blockade of H2 receptors?
(a) Decreased camp in cardiac muscle
(b) Increased camp in cardiac muscle
(c) Decreased IP3 in gastric mucosa
(d) Increased IP3 in gastric mucosa
(e) Increased IP3 in smooth muscle
Ans: A
5. Toxicities of H2 antihistamines include which one of the following?
(a) Blurred vision
(b) Diarrhea
(c) Orthostatic hypotension
(d) P450 inhibition
(e) Sleepiness
Ans: D
6. A patient undergoing cancer chemotherapy is vomiting frequently. A drug that might help in this situation is
(a) Bromocriptine
(b) Cimetidine
(c) Ketanserin
(d) Loratadine
(e) Ondansetron
Ans: E
7. Which of the following is most useful in the treatment of hyperprolactinemia ?
(a) Bromocriptine
(b) Cimetidine
(c) Ergotamine
(d) Ketanserin
(e) LSD
Ans: A
8. Drugs that can dilate bronchi during an acute asthmatic attack include all of the following except
(a) Epinephrine
(b) Terbutaline
(c) Nedocromil
(d) Theophyline
(e) Ipratropium
Ans: C
9. Which of the following is a nonselective but very potent and efficacious bonchodilator that is not active by the oral route?
(a) Aminophyline
(b) Cromolyn
(c) Epinephrine
(d) Ipratropium
(e) Metaproterenol
Ans: C
10. Which of the following is a prophylactic agent that appears to stabilize mast cells?
(a) Aminophyline
(b) Cromolyn
(c) Epinephrine
(d) Ipratropium
(e) Metaproterenol
Ans: B
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