31- Hypomagnesaemia may be caused by which of the following drugs?
1) Aminophylline
2) Cisplatin
3) Co-trimoxazole
4) Digoxin
5) Amitriptyline
Answers-2
Thiazide diuretics (not mentioned here) are a common cause of reduced serum magnesium. Cisplatin is a well recognised cause of hypomagnesaemia.
32- Which of the following concerning the conjugation of bilirubin is correct?
1) is catalysed by a glucuronyl transferase
2) occurs in the Kupfer cells of the liver
3) is increased by valproate
4) is inhibited by rifampicin
5) is impaired in Dubin-Johnson syndrome
Answers-1
b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome -
bilirubin can't Go in to the hepatocyte - unconjugated bilirubinaemia. Crigler-Najjar syndrome - bilirubin can't Conjugate - unconjugated bilirubinaemia. Dubin-Johnson
syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
33- Lipoprotein lipase deficiency is associated with:
1) Abetalipoproteinaemia
2) Combined hyperlipidaemia
3) Familial combined hyperlipidaemia
4) Familial Hypercholesterolaemia
5) Marked Hypertriglyceridaemia
Answers-5
Lipoprotein lipase deficiency is autosomal recessive and associated with increased chylomicrons and marked hypertriglyceridaemia.
34- Metabolic alkalosis is characteristically found in which of the following?
1) An infusion of sodium chloride
2) Ileostomy
3) Mineralocorticoid deficiency
4) Pyloric stenosis
5) Salicylate poisoning
Answers-4
Pyloric stenosis is associated with vomiting and the loss of stomach content – hence a metabolic alkalosis. Mineralocorticoid excess (Conn's syndrome) is
associated with a metabolic alkalosis. Ileostomy may be associated with a loss of bicarbonate ions and hence acidosis. Salicylates are themselves acidic and produce
a metabolic acidosis. A sodium chloride infusion is neutral and does not alter pH.
35- Which of the following is a recognised feature of abetalipoproteinaemia?
1) a high serum cholesterol
2) palmar xanthomas
3) advanced atherosclerotic vascular disease
4) abnormal red blood cell morphology
5) severe mental retardation
Answers-4
Acanthocytes are seen in abetalipoproteinaemia.
Retinitis pigmentosa is seen in abetalipoproteinaemia. Mental retardation is not present but motor abnormalities and neurodegenerative are seen.
More Questions & Answers:-
Page1 Page2 Page3 Page4 Page5 Page6 Page7 Page8 Page9
Page10
1) Aminophylline
2) Cisplatin
3) Co-trimoxazole
4) Digoxin
5) Amitriptyline
Answers-2
Thiazide diuretics (not mentioned here) are a common cause of reduced serum magnesium. Cisplatin is a well recognised cause of hypomagnesaemia.
32- Which of the following concerning the conjugation of bilirubin is correct?
1) is catalysed by a glucuronyl transferase
2) occurs in the Kupfer cells of the liver
3) is increased by valproate
4) is inhibited by rifampicin
5) is impaired in Dubin-Johnson syndrome
Answers-1
b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome -
bilirubin can't Go in to the hepatocyte - unconjugated bilirubinaemia. Crigler-Najjar syndrome - bilirubin can't Conjugate - unconjugated bilirubinaemia. Dubin-Johnson
syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
33- Lipoprotein lipase deficiency is associated with:
1) Abetalipoproteinaemia
2) Combined hyperlipidaemia
3) Familial combined hyperlipidaemia
4) Familial Hypercholesterolaemia
5) Marked Hypertriglyceridaemia
Answers-5
Lipoprotein lipase deficiency is autosomal recessive and associated with increased chylomicrons and marked hypertriglyceridaemia.
34- Metabolic alkalosis is characteristically found in which of the following?
1) An infusion of sodium chloride
2) Ileostomy
3) Mineralocorticoid deficiency
4) Pyloric stenosis
5) Salicylate poisoning
Answers-4
Pyloric stenosis is associated with vomiting and the loss of stomach content – hence a metabolic alkalosis. Mineralocorticoid excess (Conn's syndrome) is
associated with a metabolic alkalosis. Ileostomy may be associated with a loss of bicarbonate ions and hence acidosis. Salicylates are themselves acidic and produce
a metabolic acidosis. A sodium chloride infusion is neutral and does not alter pH.
35- Which of the following is a recognised feature of abetalipoproteinaemia?
1) a high serum cholesterol
2) palmar xanthomas
3) advanced atherosclerotic vascular disease
4) abnormal red blood cell morphology
5) severe mental retardation
Answers-4
Acanthocytes are seen in abetalipoproteinaemia.
Retinitis pigmentosa is seen in abetalipoproteinaemia. Mental retardation is not present but motor abnormalities and neurodegenerative are seen.
More Questions & Answers:-
Page1 Page2 Page3 Page4 Page5 Page6 Page7 Page8 Page9
Page10
No comments:
Post a Comment