71. Which of the following drugs is preferred for termination of paroxysmal supraventricular tachycardia
(a) Digoxin
(b) Quinidine
(c) Propranolol
(d) Verapamil
Ans: D
72. The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack
(a) Digoxin
(b) Furosemide
(c) Enalapril
(d) Amrinone
Ans: A
73. Antianginal drugs afford the following benefit/benefits
(a) Terminate anginal attacks
(b) Decrease the frequency of anginal attacks
(c) Retard the progression of coronary artery disease
(d) Both (a) and (b)
Ans: D
74. Choose the correct statement about the action of nitrates on coronary vessels
(a) They mitigate angina pectoris by increasing total coronary flow
(b) They preferentially dilate conducting arteries without affecting resistance arterioles
(c) They preferentially dilate autoregulatory arterioles without affecting the larger arteries
(d) They increase subepicardial blood flow without affecting subendocardial blood flow
Ans: B
75. Organic nitrates relax vascular smooth muscle by
(a) Increasing intracellular cyclic AMP
(b) Increasing intracellular cyclic GMP
(c) Decreasing intracellular cyclic AMP
(d) Both (b) and (c)
Ans: B
76. Select the organic nitrate which undergoes minimal first-pass metabolism in the liver
(a) Glyceryl trinitrate
(b) Isosorbide dinitrate
(c) Isosorbide mononitrate
(d) Erythrityl tetranitrate
Ans: C
77. The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is
(a) Increase in total coronary blood flow
(b) Redistribution of coronary blood flow
(c) Reduction of cardiac preload
(d) Reduction of cardiac after load
Ans: C
78. Enhanced automaticity in cardiac cells may occur because of
(a) ß-adrenergic stimulation
(b) Hypokalemia
(c) Mechanical stretch of cardiac muscles
(d) All of the above
Ans: D
79. Glyceryl trinitrate is administratered by all of the following routes except
(a) Oral
(b) Sublingual
(c) Intramuscular
(d) Intravenous
Ans: C
80. A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable.
(a) Sublingual
(b) Oral
(c) Intravenous bolus injection
(d) Slow intravenous infusion
Ans: D
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(a) Digoxin
(b) Quinidine
(c) Propranolol
(d) Verapamil
Ans: D
72. The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack
(a) Digoxin
(b) Furosemide
(c) Enalapril
(d) Amrinone
Ans: A
73. Antianginal drugs afford the following benefit/benefits
(a) Terminate anginal attacks
(b) Decrease the frequency of anginal attacks
(c) Retard the progression of coronary artery disease
(d) Both (a) and (b)
Ans: D
74. Choose the correct statement about the action of nitrates on coronary vessels
(a) They mitigate angina pectoris by increasing total coronary flow
(b) They preferentially dilate conducting arteries without affecting resistance arterioles
(c) They preferentially dilate autoregulatory arterioles without affecting the larger arteries
(d) They increase subepicardial blood flow without affecting subendocardial blood flow
Ans: B
75. Organic nitrates relax vascular smooth muscle by
(a) Increasing intracellular cyclic AMP
(b) Increasing intracellular cyclic GMP
(c) Decreasing intracellular cyclic AMP
(d) Both (b) and (c)
Ans: B
76. Select the organic nitrate which undergoes minimal first-pass metabolism in the liver
(a) Glyceryl trinitrate
(b) Isosorbide dinitrate
(c) Isosorbide mononitrate
(d) Erythrityl tetranitrate
Ans: C
77. The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is
(a) Increase in total coronary blood flow
(b) Redistribution of coronary blood flow
(c) Reduction of cardiac preload
(d) Reduction of cardiac after load
Ans: C
78. Enhanced automaticity in cardiac cells may occur because of
(a) ß-adrenergic stimulation
(b) Hypokalemia
(c) Mechanical stretch of cardiac muscles
(d) All of the above
Ans: D
79. Glyceryl trinitrate is administratered by all of the following routes except
(a) Oral
(b) Sublingual
(c) Intramuscular
(d) Intravenous
Ans: C
80. A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable.
(a) Sublingual
(b) Oral
(c) Intravenous bolus injection
(d) Slow intravenous infusion
Ans: D
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