Thursday 29 October 2015

Cardiovascular Drugs Multiple Choice Questions And Answers

21. The mechanism of action of cyclosporine involves
(a) Activation of calcineurin
(b) Binding to cyclophilin to cause inhibition of a cytoplasmic phosphatase
(c) Blockade of interleukin – 2- receptors
(d) Inhibition of phospholipase A2
(e) Suppression of bone marrow progenitors
Ans: B

22. Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility?
(a) Digoxin
(b) Lidocaine
(c) Propranolol
(d) Quinidine
(e) Verapamil
Ans: A

23. Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity?
(a) Amiodarone
(b) Lidocaine
(c) Propranolol
(d) Sotalol
(e) Prazosin
Ans: B

24. A 54-year-old woman with severe hypercholesterolemia is to be treated with a combination of niacin and atorvastatin. With this drug combination, it is important that the patient be monitored closely for signs of
(a) Agranulocytosis
(b) Gallstones
(c) Lactic acidosis
(d) Myopathy
(e) Thyrotoxicosis
Ans: D

25. Regarding verapamil, which one of the following statements is false?
(a) Angina pectoris is an important indication for the use of verapamil
(b) Contraindicated in the asthmatic patient
(c) Relaxes vascular smooth muscle
(d) Slows the depolarization phase of the action potential in AV nodal cells
(e) Used in management of supraventricular tachycardias
Ans: B

26. What drug is used to prevent embolism in the lung and during myocardial infarction?
(a) Alteplase
(b) Human growth hormone
(c) Granulocyte–macrophage colony – stimulating factor (GM–CSF)
(d) EPOGEN (EPO)
(e) None of the above
Ans: A

27. Which of the following cardiovascular agents is classified chemically as a glycoside?
(a) Nifedipine
(b) Digoxin
(c) Flecainide
(d) Cholestyramine
(e) Warfarin
Ans: B

28. Inhibition of carbonic anhydrase results in
(a) Abolition of NaHCO3 reabsorption in proximal tubule
(b) Enhanced of NaHCO3 reabsorption in proximal tubule
(c) Enhanced NAHCO3 secretion in distal tubule
(d) None of the above
Ans: A

29. Which of the following cyclotron produced radiopharmaceuticals is used for assessing regional myocardial perfusion as part of an exercise stress test?
(a) Thallous chloride 201TI USP
(b) Sodium iodide 123I
(c) Gallium citrate 67Ga USP
(d) Indium 111In pentetate
(e) Cobalt 57Co cyanocobalamin
Ans: A

30. Mary has a family history of heart disease and wonders if garlic would be beneficial to her. Which of the following statements is correct about garlic?
(a) Enteric-coated tablets release their contents in the stomach
(b) Side effects include heartburn, flatulence, and sweating
(c) The safety of garlic in pregnancy is unknown
(d) Garlic does not interact with warfarin
Ans: B

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