21. Which one of the following drugs may increase anticoagulant effects by displacement of warfarin from plasma protein binding sites and is inactive until converted in the body to an active metabolite?
(a) Buspirone
(b) Chloral hydrate
(c) Clorazepate
(d) Secobarbital
(e) Zaleplon
Ans: B
22. Which one of the following drugs has been used in the management of alcohol withdrawal states and in maintenance treatment of patient with tonic-clonic or partial seizure states? Its chronic use may lead to an increased metabolism of warfarin and phenytoin.
(a) Chlordiazepoxide
(b) Meprobamate
(c) Phenobarbital
(d) Triazolam
(e) Zolpidem
Ans: C
23. A 40-year-old patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam can be used for preanesthetic sedation in this patient without concern for excessive CNS depression because the drug is
(a) A selective anxiolytic like buspirone
(b) Actively secreted in the renal proximal tubule
(c) Conjugated extrahepatically
(d) Eliminated via the lungs
(e) Reversible by administration of naloxone
Ans: C
24. This hypnotic drug facilitates the inhibitory actions of GABA, but it lacks anticonvulsant or muscle relaxing properties and has minimal effect on sleep architecture.
(a) Buspirone
(b) Diazepam
(c) Flurazepam
(d) Phenobarbital
(e) Zaleplon
Ans: E
25. The most frequent type of drug interaction that occurs in patients using drugs of the sedative hypnotic class is
(a) Additive CNS depression
(b) Antagonism of sedative or hypnotic actions
(c) Competition for plasma protein binding
(d) Induction of liver drug-metabolizing enzymes
(e) Inhibition of liver drug-metabolizing enzymes
Ans: A
26. A 42-year-old man with a history of alcoholism is brought to the emergency room in a confused and delirious state. He has truncal ataxia and ophthalmoplegia.
The most appropriate immediate course of action is to administer.
(a) Chlordiazepoxide
(b) Disulfiram
(c) Folic acid
(d) Lorazepam
(e) Thiamine
Ans: E
27. Which one of the following statements about the bio-disposition of ethanol is accurate?
(a) Ethanol is absorbed at all levels of the gastrointestinal tract
(b) Acetic acid is the initial product of ethanol metabolism
(c) After an intravenous dose, plasma levels of ethanol are lower in women than in men
(d) The elimination of ethanol follows first-order kinetics
(e) Alcohol dehydrogenase exhibits genetic variability
Ans: A
28. Following is GABAA agonist
(a) Muscimol
(b) Baclofen
(c) Bicuculline
(d) None of the above
Ans: A
29. Chronic use of ethanol is reported to increase
(a) Alcohol dehydrogenase
(b) Aldehyde dehydrogenase
(c) Microsomal ethanol-oxidizing system activity
(d) Monoamine oxidase
(e) NADH dehydrogenase
Ans: C
30. The chronic abuse of alcohol predisposes to hepatic damage following overdose of acetaminophen because ethanol
(a) Blocks acetaminophen metabolism
(b) Causes thiamine deficiency
(c) Displaces acetaminophen from plasma proteins
(d) Induces liver drug-metabolizing enzymes
(e) Inhibits renal clearance of acetaminophen
Ans: D
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(a) Buspirone
(b) Chloral hydrate
(c) Clorazepate
(d) Secobarbital
(e) Zaleplon
Ans: B
22. Which one of the following drugs has been used in the management of alcohol withdrawal states and in maintenance treatment of patient with tonic-clonic or partial seizure states? Its chronic use may lead to an increased metabolism of warfarin and phenytoin.
(a) Chlordiazepoxide
(b) Meprobamate
(c) Phenobarbital
(d) Triazolam
(e) Zolpidem
Ans: C
23. A 40-year-old patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam can be used for preanesthetic sedation in this patient without concern for excessive CNS depression because the drug is
(a) A selective anxiolytic like buspirone
(b) Actively secreted in the renal proximal tubule
(c) Conjugated extrahepatically
(d) Eliminated via the lungs
(e) Reversible by administration of naloxone
Ans: C
24. This hypnotic drug facilitates the inhibitory actions of GABA, but it lacks anticonvulsant or muscle relaxing properties and has minimal effect on sleep architecture.
(a) Buspirone
(b) Diazepam
(c) Flurazepam
(d) Phenobarbital
(e) Zaleplon
Ans: E
25. The most frequent type of drug interaction that occurs in patients using drugs of the sedative hypnotic class is
(a) Additive CNS depression
(b) Antagonism of sedative or hypnotic actions
(c) Competition for plasma protein binding
(d) Induction of liver drug-metabolizing enzymes
(e) Inhibition of liver drug-metabolizing enzymes
Ans: A
26. A 42-year-old man with a history of alcoholism is brought to the emergency room in a confused and delirious state. He has truncal ataxia and ophthalmoplegia.
The most appropriate immediate course of action is to administer.
(a) Chlordiazepoxide
(b) Disulfiram
(c) Folic acid
(d) Lorazepam
(e) Thiamine
Ans: E
27. Which one of the following statements about the bio-disposition of ethanol is accurate?
(a) Ethanol is absorbed at all levels of the gastrointestinal tract
(b) Acetic acid is the initial product of ethanol metabolism
(c) After an intravenous dose, plasma levels of ethanol are lower in women than in men
(d) The elimination of ethanol follows first-order kinetics
(e) Alcohol dehydrogenase exhibits genetic variability
Ans: A
28. Following is GABAA agonist
(a) Muscimol
(b) Baclofen
(c) Bicuculline
(d) None of the above
Ans: A
29. Chronic use of ethanol is reported to increase
(a) Alcohol dehydrogenase
(b) Aldehyde dehydrogenase
(c) Microsomal ethanol-oxidizing system activity
(d) Monoamine oxidase
(e) NADH dehydrogenase
Ans: C
30. The chronic abuse of alcohol predisposes to hepatic damage following overdose of acetaminophen because ethanol
(a) Blocks acetaminophen metabolism
(b) Causes thiamine deficiency
(c) Displaces acetaminophen from plasma proteins
(d) Induces liver drug-metabolizing enzymes
(e) Inhibits renal clearance of acetaminophen
Ans: D
More Questions & Answers:-
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