91- Which statement is true regarding Gabapentin?
1) is a potent hepatic enzyme inducer
2) side effects typically include visual field defects with long-term use
3) therapy is best monitored through measuring plasma concentrations
4) is of particular value as monotherapy in absence attacks (petit mal)
5) requires dose adjustment in renal disease
Answers-5
92- Which of the following relate to Dopa-decarboxylase inhibitors?
1) enhance the effect of levodopa on the substantia nigra
2) reduce the extracerebral complications of L-dopa therapy
3) have anticholinergic activity
4) should not be given in combination with dopamine agonists
5) prevent L-dopa associated dyskinesias
Answers-2
93- The antibiotic combination Quinipristin and Dalfopristin are
1) effective against resistant mycobacterium TB.
2) indicated in subjects with chronic renal impairment.
3) particularly effective in the treatment of pseudomonas infection in Cystic fibrosis.
4) administered orally.
5) Effective against multi-resistant Staph Aureus
Answers-5
94- A 60-year-old Chinese man has been started on quinine for leg cramps by his General Practitioner. He presents, a week later, with 5 days of darkened urine and 2 days of increasing breathlessness, back pain and fatigue. Investigations show a haemoglobin of 7.0 g/dl and raised reticulocyte count. Which of the following best explain this drug reaction?
1) autoimmune haemolytic anaemia
2) glucose-6-phosphate dehydrogenase deficiency
3) hereditary spherocytosis
4) pyruvate kinase deficiency
5) sickle cell disease
Answers-2
95- An 18-year-old woman is admitted after taking drugs at a night-club. Which of the following features suggest she had taken Ecstasy (MDMA)?
1) A pyrexia of 40°C
2) hypernatraemia
3) hypokalaemia
4) metabolic acidosis
5) respiratory depression
Answers-1
96- A 65-year-old was advised to start oral digoxin at a dose of 250 µg daily. His physician explained that the full effect of this treatment would not be apparent for at least a week. Which one of the following pharmacokinetic variables did the physician use to give this explanation?
1) bioavailablity
2) half-life
3) plasma protein binding
4) renal clearance
5) volume of distribution
Answers-2
97- A 70-year-old male is referred by his GP for management of recently diagnosed congestive heart failure. The patient has a history of poorly controlled hypertension. Over the last three months he has been aware of deteriorating shortness of breath, fatigue, and orthopnea. Over the last month he had been commenced on Digoxin (62.5 micrograms daily), Frusemide (80 mg daily), and amiloride 10 mg. On examination he has a pulse of 96 bpm regular, a blood pressure of 132/88 mmHg. His JVP was not raised, he had some scattered bibasal crackles on auscultation with a displaced apex beat in the anterior axillary line, 6th intercostal space. Auscultation of the heart revealed no murmurs and he had peripheral oedema to the mid tibia.
Investigations showed:
electrolytes normal
serum urea concentration 17 mmol/l (NR 2-8 mmol/l)
creatinine 175 micromol/l (NR 55-110)
Serum digoxin 0.7 ng/mL {therapeutic: 1.0-2.0}
One month previously his urea had been 11 mmol/l and creatinine 110 micromol/l. An ECG reveals left ventricular hypertrophy and Chest X-ray shows cardiomegaly and calcified aorta.
What is the most appropriate next step in management?
1) Add an ACE inhibitor to the current regimen
2) Add atenolol at a dose of 25mg daily
3) Increase digoxin to 0.25 mg daily
4) Increase frusemide to 80 mg twice daily
5) Maintain on current therapy.
Answers-1
98- A 19 year old female presents with acute breathlessness. She has had asthma for approximately 3 years and recently commenced new therapy. Which agent may be responsible for this exacerbation?
1) Salmeterol
2) Theophylline
3) Beclomethasone
4) Ipratropium bromide
5) Monteleukast
Answers-1
99- The anticonvulsant Levetiracetecam
1) Is used as monotherapy for the treatment of generalised convulsions
2) Acts via the GABA receptor
3) Is associated with induction of hepatic cytochrome p450 enzymes
4) Is well absorbed via the oral route
5) Is associated with increased plasma concentrations of sodium valproate
Answers-4
100- A 40-year-old man attending a routing screening has a blood pressure of 166/100 mmHg. Two weeks later his blood pressure was 150/90 mmHg. He does not smoke. He drinks 35 units alcohol / week.
His body mass index (BMI) is 30 kg/m2 (20 - 25). What is the best management strategy?
1) amlodipine
2) atenolol
3) bendrofluazide
4) enalapril
5) lifestyle advice
Answers-5
More Questions & Answers:-
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1) is a potent hepatic enzyme inducer
2) side effects typically include visual field defects with long-term use
3) therapy is best monitored through measuring plasma concentrations
4) is of particular value as monotherapy in absence attacks (petit mal)
5) requires dose adjustment in renal disease
Answers-5
92- Which of the following relate to Dopa-decarboxylase inhibitors?
1) enhance the effect of levodopa on the substantia nigra
2) reduce the extracerebral complications of L-dopa therapy
3) have anticholinergic activity
4) should not be given in combination with dopamine agonists
5) prevent L-dopa associated dyskinesias
Answers-2
93- The antibiotic combination Quinipristin and Dalfopristin are
1) effective against resistant mycobacterium TB.
2) indicated in subjects with chronic renal impairment.
3) particularly effective in the treatment of pseudomonas infection in Cystic fibrosis.
4) administered orally.
5) Effective against multi-resistant Staph Aureus
Answers-5
94- A 60-year-old Chinese man has been started on quinine for leg cramps by his General Practitioner. He presents, a week later, with 5 days of darkened urine and 2 days of increasing breathlessness, back pain and fatigue. Investigations show a haemoglobin of 7.0 g/dl and raised reticulocyte count. Which of the following best explain this drug reaction?
1) autoimmune haemolytic anaemia
2) glucose-6-phosphate dehydrogenase deficiency
3) hereditary spherocytosis
4) pyruvate kinase deficiency
5) sickle cell disease
Answers-2
95- An 18-year-old woman is admitted after taking drugs at a night-club. Which of the following features suggest she had taken Ecstasy (MDMA)?
1) A pyrexia of 40°C
2) hypernatraemia
3) hypokalaemia
4) metabolic acidosis
5) respiratory depression
Answers-1
96- A 65-year-old was advised to start oral digoxin at a dose of 250 µg daily. His physician explained that the full effect of this treatment would not be apparent for at least a week. Which one of the following pharmacokinetic variables did the physician use to give this explanation?
1) bioavailablity
2) half-life
3) plasma protein binding
4) renal clearance
5) volume of distribution
Answers-2
97- A 70-year-old male is referred by his GP for management of recently diagnosed congestive heart failure. The patient has a history of poorly controlled hypertension. Over the last three months he has been aware of deteriorating shortness of breath, fatigue, and orthopnea. Over the last month he had been commenced on Digoxin (62.5 micrograms daily), Frusemide (80 mg daily), and amiloride 10 mg. On examination he has a pulse of 96 bpm regular, a blood pressure of 132/88 mmHg. His JVP was not raised, he had some scattered bibasal crackles on auscultation with a displaced apex beat in the anterior axillary line, 6th intercostal space. Auscultation of the heart revealed no murmurs and he had peripheral oedema to the mid tibia.
Investigations showed:
electrolytes normal
serum urea concentration 17 mmol/l (NR 2-8 mmol/l)
creatinine 175 micromol/l (NR 55-110)
Serum digoxin 0.7 ng/mL {therapeutic: 1.0-2.0}
One month previously his urea had been 11 mmol/l and creatinine 110 micromol/l. An ECG reveals left ventricular hypertrophy and Chest X-ray shows cardiomegaly and calcified aorta.
What is the most appropriate next step in management?
1) Add an ACE inhibitor to the current regimen
2) Add atenolol at a dose of 25mg daily
3) Increase digoxin to 0.25 mg daily
4) Increase frusemide to 80 mg twice daily
5) Maintain on current therapy.
Answers-1
98- A 19 year old female presents with acute breathlessness. She has had asthma for approximately 3 years and recently commenced new therapy. Which agent may be responsible for this exacerbation?
1) Salmeterol
2) Theophylline
3) Beclomethasone
4) Ipratropium bromide
5) Monteleukast
Answers-1
99- The anticonvulsant Levetiracetecam
1) Is used as monotherapy for the treatment of generalised convulsions
2) Acts via the GABA receptor
3) Is associated with induction of hepatic cytochrome p450 enzymes
4) Is well absorbed via the oral route
5) Is associated with increased plasma concentrations of sodium valproate
Answers-4
100- A 40-year-old man attending a routing screening has a blood pressure of 166/100 mmHg. Two weeks later his blood pressure was 150/90 mmHg. He does not smoke. He drinks 35 units alcohol / week.
His body mass index (BMI) is 30 kg/m2 (20 - 25). What is the best management strategy?
1) amlodipine
2) atenolol
3) bendrofluazide
4) enalapril
5) lifestyle advice
Answers-5
More Questions & Answers:-
Page1 Page2 Page3 Page4 Page5 Page6 Page7 Page8 Page9
Page10
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